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The modified description for FMD serotype Asia1 epidemic situation (Xin Yang, 31 August 2012)

There was an inappropriate description for the epidemic situation of Asia1 FMDV in China (the first sentence of the second paragraph in Background of the paper "FMD serotype Asia1 has been epidemic in China for more than 50 years" ) . The truth is that the first serotype Aisa1 FMDV of China was isolated in 1958. After that, there was no reports about the Asia 1 FMDV untill the year of 2005. So we modified the sentence to "In China, the first FMDV serotype Asia1 was isolated in 1958 ". read full comment

Comment on: Yang et al. Virology Journal, 8:175

Reply to Dr. Dusty Miller's comment. (Chandravanu Dash, 27 June 2012)

We thank Dr. Miller for his insightful comments. Our rebuttals to his comments are described... read full comment

Comment on: Dey et al. Virology Journal, 8:531

Conclusions not supported by the data (A Dusty Miller, 13 June 2012)

This report claims two major conclusions (first and last paragraphs of the... read full comment

Comment on: Haleyur Giri Setty et al. Virology Journal, 8:423

Insufficient evidence (Laura Kasman, 30 March 2012)

In my opinion, this report lacks some critical pieces of... read full comment

Comment on: Gaston et al. Virology Journal, 9:21

Is ECV304 an endothelial cell line? (Masanori Terajima, 30 March 2012)

I am surprised to see that ECV304 cell line is still being used as an endothelial cell line after two papers in 1999 and 2000 clearly showed that it is not.

The two papers are

1: Dirks WG, MacLeod RA, Drexler HG. ECV304 (endothelial) is really T24 (bladder carcinoma): cell line cross- contamination at source. In Vitro Cell Dev Biol Anim. 1999 Nov-Dec;35(10):558-9. PubMed PMID: 10614862.

2: Brown J, Reading SJ, Jones S, Fitchett CJ, Howl J, Martin A, Longland CL, Michelangeli F, Dubrova YE, Brown CA. Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: a comparison with the human bladder cancer derived epithelial cell line T24/83. Lab Invest. 2000 Jan;80(1):37-45. PubMed PMID: 10653001. read full comment

Comment on: Jia et al. Virology Journal, 8:74

Conclusions not supported by the data (A Dusty Miller, 13 January 2012)

This report claims two major conclusions (last paragraph of Abstract):... read full comment

Comment on: Dey et al. Virology Journal, 8:531

Cure? (Karla Bravo, 04 January 2012)

Would this vaccine work as a cure for people already infected or only as a prevention vaccine? read full comment

Comment on: Wang et al. Virology Journal, 8:232

Standing on the shoulders of giants... (Luis Branco, 27 October 2011)

After this manuscript was published in preliminary form we recalled a report by Niklasson, Jahrling and Peters published in 1984 by the Journal of Clinical Microbiology entitled "Detection of Lassa virus antigens and Lassa virus-specific immunoglubulins IgG and M by enzyme-linked immunosorbent assay" that reported persistence of LASV-specific IgM in a relevant nonhuman primate model of LF. Niklasson, Jahrling and Peters observed that rhesus macaques surviving LF continued to generate significant serum titers of LASV-specific IgM until at least day 532 post-infection. The authors considered that, "this unexpected persistence of virus-specific IgM in the nonhuman primate model deserves further investigation and should also be evaluated in patients. The finding raises concerns about possible... read full comment

Comment on: Branco et al. Virology Journal, 8:478

Chromosomally integrated HHV-6 in renal transplant patients (Paolo Lusso, 27 October 2011)


The recent report by Csoma et al.1 identifies HHV-6A as the viral variant most frequently detected in patients who received renal transplantation, but we noticed some important drawbacks in the study that suggest caution in the interpretation of these results. First and foremost, although the authors introduce the issue of chromosomally integrated HHV-6 (ciHHV-6) in the discussion, they did not test their patients for ciHHV-6. Individuals with ciHHV-6 have high levels of both cell-associated and cell-free HHV-6 DNA in the absence of active infection2. For these reasons, clinical studies should exclude, or at least consider separately, such individuals. Although in this study viral load data are not specified for each PCR-positive patient (only mean values and... read full comment

Comment on: Csoma et al. Virology Journal, 8:403

Value of cell studies that reflect the natural situation and whether, histiocyte-derived U-937 cells are the cell-line of choice, for studies of HIV infection interactions of monocytes and macrophages (Garry Lynch, 27 October 2011)

In the article by Ferrucci et al `Cellular phenotype impacts human immunodeficiency virus type 1 viral protein R subcellular localization¿ Virology Journal 8: 397 (10th of August) 2011 (1), applauded is their approach taken in this study of HIV Vpr protein localization, using cells that more closely represent the types of cells infected in nature as compared to numerous previous studies that deployed laboratory cell-lines (e.g., HeLa cells) derived from cell types that do not naturally harbour HIV infection. The latter approach has undoubtedly been useful and beneficial in many different situations to reveal various important aspects of HIV infection and its interactions. However, given the inherent and specialised compositions and proteome(s) of each different cell type that underpins... read full comment

Comment on: Ferrucci et al. Virology Journal, 8:397

The size of products of 5' RACE-PCR (qiang ruan, 19 July 2011)

Eight products obtained from the 5' RACE-PCR were approximately 100, 150, 200, 350, 500, 700, 900, and 2500bp. read full comment

Comment on: He et al. Virology Journal, 8:299

Virology Journal Comments: upfront and available (Robert Garry, 31 May 2011)

One of the most important features of the new look Virology Journal (and other Biomed Central journals) is that Comments section is now featured on the ¿front page.¿

We would like to encourage the virology community to make use of this important feature to contribute to the on-going ¿peer review¿ of each article that appears in Virology Journal. The Comments sections is moderated; however, all constructive criticisms and insightful commentary are welcome. read full comment

Comment on: Branco et al. Virology Journal, 7:279

The tailspike protein gp17 of phage LSB-1 is not an endosialidase (David Schwarzer, 31 May 2011)

The authors Chai et al. present a novel phage named LSB-1. By analyzing the genome they could identify this phage belonging to the T7-like phage family. The phylogenetic trees in Figures 5¿7 of their study nicely illustrate the close relationship to the other T7-like phages which were used for comparison. In these three phylogenetic trees, the phage LSB-1 was found to be closely related to coliphage K1F. This T7-like phage infects the pathogen Escherichia coli K1. These bacteria are encapsulated by a thick capsule composed of ¿2,8-linked sialic acid homopolymers (polySia). The tailspike proteins of K1-phages that are required to specifically bind and degrade the capsule of K1 strains are named endosialidases. Endosialidases are common to all known K1-phages so far and moreover K1-... read full comment

Comment on: Chai et al. Virology Journal, 7:255

Sentence corrections in materials & methods (Kyoko Shinya, 31 May 2011)

Please find correct information in bellow:

HEK293T human embryonic kidney cells were maintained in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% fetal calf serum, and Madin-Darby canine kidney (MDCK) cells were maintained in minimal essential medium (MEM) with 5% newborn calf serum. read full comment

Comment on: Shinya et al. Virology Journal, 8:97

typographical error in abstract (Laura Kasman, 31 May 2011)

I think the Results section of the abstract is meant to read:
... The nucleotide identity for the three JCV viruses is 90, 83, and 85% for the S, M, and L segments respectively whereas the percent identity for the predicted amino acid sequences of the N, NSS, M poly, GN, NSM, GC, and L proteins was 97, 91, 94, 98, 91, 94, and 97%, respectively.
Currently it says identify read full comment

Comment on: Bennett et al. Virology Journal, 8:136

Modify some minor mistakes (Shunchuan Zhang, 31 May 2011)

1. In the legend of the Figure 2 B, ¿by rabbit anti-tgK monoclonal antibody¿should be modified as ¿by rabbit anti-tgK polyclonal antibody¿.
2. Under the Figure 2, the right passage ¿The neutralization titer of the rabbit anti-tgK polyclonal antibody was evaluated by micro neutralization test¿¿¿. In this passage, the second sentence¿ ¿each well had 250 ¿l cell¿ should be modified as ¿each well had 25¿l cell¿; and also in the fourth sentence¿ ¿which was diluted from the virus stock suspension (TCID50 = 10-5.567)¿ should be modified as ¿which was diluted from the virus stock suspension (TCID50 = 10-5.567/100¿l)¿. read full comment

Comment on: Zhang et al. Virology Journal, 7:241

Dynamic Distribution and Tissue Tropism of Classical Swine Fever Virus in Experimentally Infected Pigs (Qin Wang, 31 May 2011)

Dear Virology Journal Editorial... read full comment

Comment on: Liu et al. Virology Journal, 8:201

Correction: Forward ends are "less" permuted than the reverse ends (cun li, 31 May 2011)

The overall frequencies of forward HFSs are greater than that of the reserve HFSs (Figure 7 and additional file 3), again suggesting that the replication and packaging of the genome is asymmetric and that the forward ends (5' relative to the genome) are less permuted than the reverse ends (3' relative to the genome). read full comment

Comment on: Jiang et al. Virology Journal, 8:194

Article Retraction (Robert Garry, 11 August 2010)

As Editor-in-Chief of Virology Journal I wish to apologize for the publication of the article entitled ''Influenza or not influenza: Analysis of a case of high fever that happened 2000 years ago in Biblical time”, which clearly does not provide the type of robust supporting data required for a case report and does not meet the high standards expected of a peer-reviewed scientific journal. Virology Journal has always operated an exceptionally high standard of thorough peer review; this article has clearly not met these thresholds for balance and supporting data and as such, the article will be retracted. I should like to apologize for any confusion or concern that this article may have caused among our readership, or more widely.

Whilst only ever intended as an opinion... read full comment

Comment on: Hon et al. Virology Journal, 7:169

Peer review or not peer review (Robert Garry, 11 August 2010)

This article was read by an Editor and peer reviewed.

Both reviewers recommended acceptance after required modifications. read full comment

Comment on: Hon et al. Virology Journal, 7:169

Pay to play or serious journal? (Paul Gray, 11 August 2010)

The content of this "case report" aside, it is unclear how this case report meets any of the normal standards of a scientific article or the minimal standards of any journal other than someone actually paid to have it published.

According to the Journal's Instructions for Authors

"Case reports submissions will be assessed by the Editors and will be sent for peer review if considered appropriate for the journal."

I would like to know whether the editor actually read this submission and decided that no peer review was necessary.

I had my qualms about BioMedCentral journals and this only makes then stronger. read full comment

Comment on: Hon et al. Virology Journal, 7:169

Concerns the genetic analysis of Chikungunya Virus strain China 2008 FD080178 and SD08Pan (Rishi Kumar Singh, 14 July 2010)

The article concerns the genetic analysis of Chikungunya Virus strain China 2008 FD080178, in which the authors described the variation in amino acid E1 gene, a shift of Ala to Val at amino acid 306. We are surprised to observe this information, because in Table.3 shows the unique amino acid changes, but here the E1 gene showed protein position 316 is mutated. The position mentioned in E1 A306V is wide of the mark, and the concrete protein position is E1 A316V, which only mentioned in Table.3 with position 1125 polypeptide E1 316 Ala to Val.The persuasion to author for evaluates the right mutation at this point.
We also suggested that, author missed an important point mutation at another protein position 1078 of E1 V269M in strain SD08Pan and not discussed in present article, this... read full comment

Comment on: Zheng et al. Virology Journal, 7:8

Hepatitis C virus infection in blood donors from Castilla y Leon, Spain. (Eva López García, 14 July 2010)

To The Editor:
In the January 25th issue of Virology Journal, Sosa-Jurado and colleagues analyzed the prevalence of antibodies to hepatitis C virus (HCV) in blood donors from Puebla, Mexico. The prevalence found in this study (0.84%; 515/61553) [1] is situated in an intermediate position in respect to the other series that have been studied in other countries like Germany (0.29%; 3/1020) [2], Australia (0.55%; 190/34725) [3], India (0.61%; 37/6109) [4], Brazil (1.15%; 298/25891) [5], Indonesia (2.13%; 161/7572) [6], Iran (2.32%; 55/2376) [7], Niger (2.9%; 29/1000) [8] or Georgia (7.8%; 43/553) [9].
In Spain, the prevalence of infection for HCV has been an objective of small studies that were carried out in general population [10,11], as well as in specific groups like pregnant... read full comment

Comment on: Sosa-Jurado et al. Virology Journal, 7:18

JC Virus & Cancer (Debra Andrews, 17 June 2010)

Interesting article. I'm familiar with a case where the patient battled Chronic Lymphocytic Leukemia, Hodgkins Lymphoma and finally Progressive Multifocal Leukoencephalopathy. He died 3 days ago. He constantly had severe colon pain and strange bowel habits for years prior to any cancer diagnosis. Nothing could ever be found by colonoscopy, barium enema or MRI. Possibly JCV was lurking in his gastrointestinal tract for years? read full comment

Comment on: Coelho et al. Virology Journal, 7:42

Clarification of Table 2 (Jônatas Abrahão, 03 May 2010)

It was a typo. Were analyzed 5 samples from Espiríto Santo State.
Thanks for your contribution. read full comment

Comment on: Abrahão et al. Virology Journal, 6:140