Trends in the prevalence and distribution of HTLV-1 and HTLV-2 infections in Spain
1 Infectious Diseases Department, Hospital Carlos III, Calle Sinesio Delgado 10, Madrid 28029, Spain
2 Service of Microbiology, Hospital Conxo, Santiago de Compostela, Spain
3 Service of Microbiology, Hospital Vall d'Hebron, Barcelona, Spain
4 Service of Microbiology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
5 Service of Microbiology, Hospital Clínico Universitario, Valladolid, Spain
6 Service of Microbiology, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain
7 CIBER in Public Health and Epidemiology, Hospital Universitario Virgen del Rocío, Seville, Spain
8 Service of Microbiology, Hospital Universitario Puerta del Mar, Cádiz, Spain
9 Service of Microbiology Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
10 Service of Microbiology, Hospital Cristal-Piñor, Orense, Spain
11 Infectious Disease Unit, Hospital General, Elche, Spain
12 Service of Microbiology, Hospital Miguel Servet, Zaragoza, Spain
13 Center of Biomedical Diagnostic, Hospital General Universitario, Valencia, Spain
14 Centro Sanitario Sandoval, Madrid, Spain
15 Service of Microbiology, Complejo Hospitalario, Pontevedra, Spain
16 Service of Microbiology, Complejo Hospitalario Virgen de la Salud, Toledo, Spain
Virology Journal 2012, 9:71 doi:10.1186/1743-422X-9-71Published: 23 March 2012
Although most HTLV infections in Spain have been found in native intravenous drug users carrying HTLV-2, the large immigration flows from Latin America and Sub-Saharan Africa in recent years may have changed the prevalence and distribution of HTLV-1 and HTLV-2 infections, and hypothetically open the opportunity for introducing HTLV-3 or HTLV-4 in Spain. To assess the current seroprevalence of HTLV infection in Spain a national multicenter, cross-sectional, study was conducted in June 2009.
A total of 6,460 consecutive outpatients attending 16 hospitals were examined. Overall, 12% were immigrants, and their main origin was Latin America (4.9%), Africa (3.6%) and other European countries (2.8%). Nine individuals were seroreactive for HTLV antibodies (overall prevalence, 0.14%). Evidence of HTLV-1 infection was confirmed by Western blot in 4 subjects (prevalence 0.06%) while HTLV-2 infection was found in 5 (prevalence 0.08%). Infection with HTLV types 1, 2, 3 and 4 was discarded by Western blot and specific PCR assays in another two specimens initially reactive in the enzyme immunoassay. All but one HTLV-1 cases were Latin-Americans while all persons with HTLV-2 infection were native Spaniards.
The overall prevalence of HTLV infections in Spain remains low, with no evidence of HTLV-3 or HTLV-4 infections so far.