Table 3

Genotype frequency of toll-like receptor (TLRs) polymorphisms in children with pandemic A/H1N1 influenza infection by disease severity
Polymorphism genotypes A/H1N1/2009-positive children hospitalised because of pneumonia(n=18) A/H1N1/2009-positive children discharged with a diagnosis other than pneumonia(n=33)
Frequency Viral load (mean log10cp/mL ± SD) Frequency Viral load (mean log10cp/mL ± SD)
TLR2 rs5743708
 GG 17 (94.4) 7.43 ± 1.30 32 (97.0) 7.06 ± 1.57
 GA 1 (5.6) 3.88 1 (3.0) 8.29
p-value, HWE 0.90 0.93
TLR3 rs5743313
 CC 0 (0.0)* NA 26 (78.8) 6.94 ± 1.45
 TT 0 (0.0) NA 4 (12.1) 7.24 ± 2.42
 CT 18 (100.0)* 7.23 ± 1.51 3 (9.1) 8.07 ± 1.33
p-value, HWE <0.001 <0.001
TLR3 rs5743315
 CC 15 (83.3) 7.26 ± 1.66 31 (93.9) 7.12 ± 1.59
 AC 3 (16.7) 7.10 ± 0.36 2 (6.1) 6.69 ± 1.25
p-value, HWE 0.70 0.86
TLR4 rs4986790
 AA 16 (88.9) 7.12 ± 1.53 30 (90.9) 7.00 ± 1.56
 AG 2 (11.1) 8.14 ± 1.41 3 (9.1) 8.01 ± 1.57
p-value, HWE 0.80 0.78
TLR4 rs4986791
 CC 17 (94.4) 7.24 ± 1.56 29 (87.9) 7.00 ± 1.56
 TT 0 (0.0) NA 0 (0.0) NA
 CT 1 (5.6) 7.14 4 (12.1) 8.01 ± 1.57
p-value, HWE 0.90 0.71

HWE: Hardy-Weinberg equilibrium; NA: not available; TLR: toll-like receptor. Percentages in parentheses. *p<0.0001 vs A/H1N1/2009-positive children discharged with a diagnosis other than pneumonia; no other significant between-group difference.

Esposito et al.

Esposito et al. Virology Journal 2012 9:270   doi:10.1186/1743-422X-9-270

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