Table 2

Genotype frequency of toll-like receptor (TLR) polymorphisms in the study population
Polymorphism genotypes A/H1N1/2009-positive children admitted because of ILI(n=51) A/H1N1/2009-negative children admitted because of ILI(n=221) Healthy controls(n=164)
TLR2 rs5743708
 GG 49 (96.1) 218 (98.6) 161 (98.2)
 GA 2 (3.9) 3 (1.4) 3 (1.8)
p-value, HWE 0.89 0.92 0.91
TLR3 rs5743313
 CC 26 (51.0) 124 (56.1) 92 (56.1)
 TT 4 (7.8) 12 (5.4) 9 (5.5)
 CT 21 (41.2) 85 (38.5) 63 (38.4)
p-value, HWE 0.93 0.60 0.67
TLR3 rs5743315
 CC 46 (90.2) 208 (94.1) 149 (90.9)
 AC 5 (9.8) 13 (5.9) 15 (9.1)
p-value, HWE 0.71 0.65 0.54
TLR4 rs4986790
 AA 46 (90.2) 202 (91.4) 148 (90.2)
 AG 5 (9.8) 19 (8.6) 16 (9.8)
p-value, HWE 0.71 0.50 0.51
TLR4 rs4986791
 CC 46 (90.2) 203 (91.9) 148 (90.2)
 TT 0 (0.0) 1 (0.5) 0 (0.0)
 CT 5 (9.8) 17 (7.6) 16 (9.8)
p-value, HWE 0.71 0.33 0.51

HWE: Hardy-Weinberg equilibrium; ILI: influenza-like illness; TLR: toll-like receptor. Percentages in parentheses. No significant between-group difference.

Esposito et al.

Esposito et al. Virology Journal 2012 9:270   doi:10.1186/1743-422X-9-270

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