Email updates

Keep up to date with the latest news and content from Virology Journal and BioMed Central.

Open Access Research

Evidence for natural recombination between mink enteritis virus and canine parvovirus

Jianke Wang, Shipeng Cheng*, Li Yi, Yuening Cheng, Shen Yang, Hongli Xu, Hang Zhao, Xijun Yan and Hua Wu

Author Affiliations

State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, 4899 Juye Street, Changchun, 130112, China

For all author emails, please log on.

Virology Journal 2012, 9:252  doi:10.1186/1743-422X-9-252

Published: 30 October 2012


A virus was isolated from mink showing clinical and pathological signs of enteritis in China. This virus, designated MEV/LN-10, was identified as mink enteritis virus (MEV) based on its cytopathic effect in the feline F81 cell line, the hemagglutination (HA) and hemagglutination inhibition (HI) assay, electron microscopy (EM) and animal infection experiments. The complete viral genome was cloned and sequenced. Phylogenetic and recombination analyses on the complete MEV/LN-10 genome showed evidence of recombination between MEV and canine parvovirus (CPV). The genome was composed of the NS1 gene originating from CPV while the VP1 gene was of MEV origin. This is the first demonstration of recombination between a CPV and MEV in nature. Our findings not only provide valuable evidence indicating that recombination is an important genetic mechanism contributing to the variation and evolution of MEV, but also that heterogeneous recombination can occur in the feline parvovirus subspecies.

Parvovirus; Mink enteritis virus; Recombination