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Open Access Research

Population-based study on the prevalence of and risk factors for human papillomavirus infection in Qujing of Yunnan province, Southwest China

Sun Lu-lu1, Jin Qiong1, Li Hui2, Zhou Xian-rong3, Song Zhi-qin4, Cheng Xue-mei1, Tao Tao1, Liang Bing1, Xu Lin5, Wang Yu-rong6, Zhen Yan7, He Ji-wen8 and Shen Keng1*

Author Affiliations

1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing 100730, China

2 Department of Epidemiology, Institute of Basic Medical Sciences, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing 100730, China

3 Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China

4 Department of Obstetrics and Gynecology, PLA Navy General Hospital, Beijing 100000, China

5 Department of Obstetrics and Gynecology, The first hospital of Kunming University, Yunnan 650032, China

6 Department of Obstetrics and Gynecology, Qujing Maternal and Child Care Service Centre, Yunnan 655000, China

7 Vice Chairman of the National Women's Federation, Beijing 100730, China

8 Director of Qujing Health Care Bureau, Qujing 655000, China

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Virology Journal 2012, 9:153  doi:10.1186/1743-422X-9-153

Published: 8 August 2012

Abstract

Background

Human papillomavirus (HPV) infection causes cervical cancer and premalignant lesions of the cervix. Prevalence of HPV infection and HPV genotypes vary among different regions. However there is no data on the prevalence of HPV infection and HPV genotypes from southwest China. This study was undertaken to determine the prevalence of and risk factors for HR-HPV infection in Qujing of Yunnan province, southwest China to provide comprehensive baseline data for future screening strategies.

Methods

A sample of 5936 women was chosen by the multi-stage stratified cluster sampling method with selection probabilities proportional to size (PPS). An epidemiological questionnaire was conducted via a face-to-face interview and cervical specimens were taken for HPV DNA testing by Digene Hybrid Capture 2 (HC2) test. HPV Genotyping Reverse Hybridization Test was used for HPV genotyping. Proportions were compared by Chi-squared tests, and logistic regression was utilized to evaluate risk factors.

Results

The median age was 38 years and the inter-quartile range was from 31 years to 47 years. 97.3% of the study population was Han nationality. Overall prevalence of HR-HPV infection was 8.3% (494/5936) and bimodal age distribution of HPV infection was observed. The five most prevalent HR-HPV genotypes were HPV-16(3.4%), HPV-56(1.7%), HPV-58(1.4%), HPV-33(1.2%) and HPV-52(0.88%). Multiple HPV infections were identified in 50.5% (208/412) of the positive genotyping specimens. Multivariate logistic regression model indicated that parity (OR = 1.35, 95% CI: 1.18-1.53, p < 0.0001) was a risk factor for HR-HPV infection, and age of 50–65 years (OR = 0.60, 95% CI: 0.45-0.80, p = 0.0005), being married or in stable relationship (OR = 0.55, 95% CI: 0.31-0.96, p = 0.035) were protective factors.

Conclusions

This study provided baseline data on HR-HPV prevalence in the general female population in Qujing of Yunnan province, southwest China. The finding of multiple HPV infections and bimodal age distribution revealed that HPV screening is necessary for perimenopausal women in future.

Keywords:
Human papillomavirus; Genotype; Cervix; Epidemiology; China