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Co-circulation of two genotypes of dengue virus serotype 3 in Guangzhou, China, 2009

Tao Jiang1, Xue-Dong Yu1, Wen-Xin Hong2, Wei-Ze Zhou3, Man Yu1, Yong-Qiang Deng1, Shun-Ya Zhu1, E-De Qin1, Jian Wang2, Cheng-Feng Qin1* and Fu-Chun Zhang2*

Author Affiliations

1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, No.20 Dongda Street, Fengtai District, Beijing, 100071, China

2 Guangzhou No.8 People’s Hospital, Guangzhou Medical College, Guangzhou, 510060, China

3 The Third People’s Hospital of Huizhou, Huizhou, 516002, China

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Virology Journal 2012, 9:125  doi:10.1186/1743-422X-9-125

Published: 22 June 2012

Abstract

Dengue is emerging as the most important mosquito borne viral disease in the world. In mainland China, sporadic and large outbreaks of dengue illness caused by the four serotypes of dengue virus (DENV-1 to DENV-4) have been well documented. Guangdong province is the major affected area in China, and DENV-1 has dominantly circulated in Guangdong for a long time. In this study, a family cluster of DENV-3 infection in Guangzhou was described. Three cases were diagnosed as dengue fever based on clinical manifestation, serological and RT-PCR assays. Two DENV-3 strains were isolated in C6/36 cells and the complete genome sequences were determined. Phylogenetic analysis revealed that the new DENV-3 isolates from the family cluster were grouped within genotype III. Considering the fact that several DENV-3 strains within genotype V were also identified in Guangzhou in 2009, at least two genotypes of DENV-3 co-circulated in Guangzhou. Careful investigation and virological analysis should be warranted in the future.

Keywords:
Dengue virus type 3; Family cluster; Genotype; Co-circulation