Table 3

Antiviral effect of prestimulation by Toll-like receptor-specific ligands.

TLR stimulation

Virus strain

Ratio of MLD50 (log10EID50) between LPS-pretreated and mock-treated mice


TLR2 a

A/Vietnam/1203/04

0

TLR4 b

A/Vietnam/1203/04

1.0

TLR2

Sp HA/WSN c

0.76

TLR4

Sp HA/WSN c

0.49


aSynthetic mycoplasmal lipoprotein (FSL-1)

bLPS of E. coli K12 msbB (LPS agonist)

cReassortant possessing the HA segment from influenza A/South Carolina/1918 (H1N1) and the remaining seven viral RNA segments from A/WSN/33 (H1N1).

Shinya et al. Virology Journal 2011 8:97   doi:10.1186/1743-422X-8-97

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