Table 1

Antiviral effect of intranasal prestimulation by lipopolysaccharide against influenza A/Puerto Rico/8/34.

LPS (mg/kg) a

Pretreatment time

Ratio of MLD50 (log10EID50) between LPS-pretreated and mock-treated miceb


0.15625

7 days

0

3 days

1.0

24 hrs

0

12 hrs

0

0.3125

7 days

0.6

3 days

1.26

24 hrs

0

12 hrs

0

0.625

7 days

1.0

3 days

1.6

24 hrs

1.0

12 hrs

0.3

1.25

7 days

0

3 days

1.94

24 hrs

0.94

12 hrs

0.94

6 hrs

0.24

2.5

7 days

1.0

3 days

1.3

24 hrs

1.0

12 hrs

0


aEscherichia coli (serotype O26:B6)-derived lipopolysaccharide (LPS), MLD50 = 36.4 (mg/kg)

b "0" would be no difference and "1.0" would indicate that 10 times more virus is need to kill 50% of infected animals when treated with the indicated amount of LPS.

Shinya et al. Virology Journal 2011 8:97   doi:10.1186/1743-422X-8-97

Open Data