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Open Access Research

HPV prevalence and type distribution in women with or without cervical lesions in the Northeast region of Romania

Ramona Gabriela Ursu1*, Mircea Onofriescu2, Dragoş Nemescu2 and Luminiţa-Smaranda Iancu1

Author Affiliations

1 Microbiology Department, "Grigore T. Popa" University of Medicine and Pharmacy, Universitatii Str. NO 15, Iaşi 700115, Romania

2 Gynecology Department, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Universitatii Str. NO 15, Iaşi 700115, Romania

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Virology Journal 2011, 8:558  doi:10.1186/1743-422X-8-558

Published: 22 December 2011

Abstract

Background

Cervical cancer is a major public health problem worldwide. While Romania has the highest incidence of cervical cancer in Europe, the prevalence of HPV has not been evaluated. We report the first data on HPV prevalence and type distribution in Northeast Romania.

Methods

HPV prevalence and genotype distribution was investigated in 514 consecutively women with or without cervical lesions in Northeast Romania. Genotyping was performed with Linear Array Genotyping/Roche kit.

Results

In our study group, 192/514 (37.4%) patients were positive for HPV (infected with single and with multiple HPV types). Most frequent types were: 16 (10.5%), 53 (5.44%), 51 (5.05%), 52 (4.08%) 18 (2.91%) and 31 (2.73%).

Conclusions

Infection with high risk types of HPV is common in Northeast Romania. Enhanced and systematic screening for cervical cancer is needed. Our results call for the implementation of a National HPV vaccine program in Romania.

Keywords:
HPV; Screening; Cytology; Prevalence; Persistence; Vaccination