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Protection from avian influenza H5N1 virus infection with antibody-impregnated filters

Yoichiro Kamiyama1, Kazuhide Adachi2, Ekowati Handharyani3, Retno Damajanti Soejoedono3, Takayuki Kusano1, Marie Inai2, Masaya Tsukamoto2, Seizaburo Kashiwagi4 and Yasuhiro Tsukamoto2*

Author Affiliations

1 Life Science Research Laboratories, Research & Development Management Headquarters, Fujifilm Corporation, 577 Ushijima, Kaisei-machi, Ashigarakami-gun, Kanagawa 258-8577, Japan

2 Department of Animal Hygiene, Graduate School of Biology and Environmental Sciences, Kyoto Prefecture University, 1-5 Nakaragicho, Kyoto 606-8522, Japan

3 Faculty of Veterinary Medicine, Bogor Agriculture University, JL. Agatis, Kampus IPB Darmaga, Bogor 16680, Indonesia

4 National Kyushu Medical Center, 1-8-1 Chiyukihama, Chuo-Ku, Fukuoka 810-8563, Japan

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Virology Journal 2011, 8:54  doi:10.1186/1743-422X-8-54

Published: 8 February 2011

Abstract

There is worldwide concern over the possibility of a new influenza pandemic originating from the highly pathogenic avian H5N1 influenza viruses. We herein demonstrate that functional air filters impregnated with ostrich antibodies against the hemagglutinin of the H5N1 virus protect chickens from death by H5N1 transmission. These results suggest that the use of ostrich antibody-impregnated filters might be a powerful way to prevent the transmission of H5N1.