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Seroprevalence and risk factors of Kaposi's sarcoma-associated herpesvirus infection among the general Uygur population from south and north region of Xinjiang, China

Hui Wang1, Jian Liu1, Dilimulati1, Liang Li1, Zhihui Ren1, Hao Wen1 and Xing Wang12*

Author Affiliations

1 The First Teaching Hospital of Xinjiang Medical University,1 Liyu Shan Road,Urumqi, Xinjiang, People's Republic of China

2 Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China

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Virology Journal 2011, 8:539  doi:10.1186/1743-422X-8-539

Published: 14 December 2011



Kaposi sarcoma (KS) is a complex multifocal neoplasm and is the major cause of death for about 50% of acquired immunodeficiency syndrome (AIDS) patients. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus with a causal role in the development of all types of KS. KS is prevalent among the Uygur people in Xinjiang, especially in south area. Here we carried out a cross-sectional study among 1534 general Uygur individuals from south and north region of Xinjiang to assess the seroprevalence of KSHV and to identify the potential correlation between KSHV seroprevalence and KS incidence.


Seroprevalence of KSHV in South and North Xinjiang was 23.1% and 25.9%, respectively. Older age was independently associated with higher KSHV seroprevalence. In subjects from South Xinjiang, lower educational level and reported drinking were each independently associated with higher KSHV seroprevalence. Furthermore, the antibody titer was significantly lower in both south and north KSHV seropositive individuals compared with KS patients, as analyzed by gradient dilution (P < 0.001).


KSHV is highly prevalent in the general Uygur population in both South and North Xinjiang. Interestingly, the infection rate of KSHV in these two geographical areas did not correlate well with KS incidence. Perhaps unknown factors exist that promote the progression of KSHV infection to KS development in the local minority groups.

Kaposi's sarcoma-associated herpesvirus (KSHV); Kaposi's sarcoma (KS); seroprevalence; Uygur people; risk factors; Xinjiang