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Epidemiology and immunoprotection of nephropathogenic avian infectious bronchitis virus in southern China

Qingmei Xie1*, Jun Ji1, Jingwei Xie12, Feng Chen12, Manshan Cai3, Baoli Sun1, Chunyi Xue4, Jingyun Ma1 and Yingzuo Bi1

  • * Corresponding author: Qingmei Xie

  • † Equal contributors

Author Affiliations

1 College of Animal Science, South China Agricultural University, Guangzhou 510642, China

2 Guangdong Wen's Foodstuffs Group Co. Ltd., Yunfu 527439, China

3 State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

4 State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-Sen University, Guangzhou 510006, China

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Virology Journal 2011, 8:484  doi:10.1186/1743-422X-8-484

Published: 27 October 2011



In last three years, 96 suspected poultry farms from different provinces in China were diagnosed for avian infectious bronchitis (IB) survey. Finally, 221 IBV strains were confirmed by dwarf embryo test and RT-PCR assay. By virus recovery trials, 187 of the isolates caused the birds died or distressed from nephritis, which was accordant with the clinical record.


Based on epidemiology analysis of recent field isolates of nephropathogenic IB in vaccinated farms in China, YL6 strain were used for vaccination and evaluated by antibody titer and challenge tests. The immunoprotection test indicated that the practical application of vaccine based on the recent field strains could finely facilitate controlling the nephropathogenic IB.


Our study was aim at setting a guide for safeguard against nephropathogenic IBV-caused disease in China.