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Open Access Review

Research advances on flotillins

Feng Zhao1, Jie Zhang1, Yong-Sheng Liu1*, Li Li2 and Ya-Li He3

Author Affiliations

1 State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Lanzhou, 730046, Gansu, P.R. China

2 The People's Government of Huaikou Town in Jintang County of Chengdu City , Chengdu, 610404, Sichuan, P.R. China

3 School of Public Health, Lanzhou university, Lanzhou, 730000, Gansu, P.R. China

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Virology Journal 2011, 8:479  doi:10.1186/1743-422X-8-479

Published: 25 October 2011

Abstract

The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well-conserved from fly to man, their exact functions remain controversial. In this review, we summarize the structure of flotillins and some functions of them, such as regulating axon regeneration, endocytosis, T cell activation, insulin signaling, membrane protein recruitment, roles in the progression of some diseases and so on.

Keywords:
Flotillin-1; Flotillin-2; Lipid raft; Signal transduction; Prion protein; GPI-anchored proteins