Table 3 |
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|
Evolutionary highly conserved motifs in Influenza A virus |
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|
Segment |
Motif |
Length |
start position (consensus sequence) |
End Position (Consensus Sequence) |
H5N1 Start Position |
H5N1 End Position |
Sequence |
Repeated Positions On H5N1 |
Mapping on Conserved Regions |
|
|
|||||||||
|
1 (PB2) |
1 |
9 |
1652 |
1660 |
1631 |
1639 |
TGATGTGGG |
R8 |
|
|
|
|||||||||
|
1 (PB2) |
2 |
6 |
2254 |
2259 |
2232 |
2237 |
GAAACG |
(2238 - 2243) |
R12 |
|
|
|||||||||
|
1 (PB2) |
3 |
11 |
2273 |
2283 |
2251 |
2261 |
AGCATACTTAC |
R12 |
|
|
|
|||||||||
|
1 (PB2) |
4 |
9 |
2291 |
2299 |
2269 |
2277 |
CAGACAGCG |
R12 |
|
|
|
|||||||||
|
1 (PB2) |
1 |
6 |
914 |
919 |
889 |
894 |
ATGATG |
(1243 - 1248) (1246 - 1251) (1624 - 1629) (1994 - 1999) |
R8 |
|
|
|||||||||
|
2 (PB1) |
2 |
11 |
1268 |
1278 |
1243 |
1253 |
ATGATGATGGG |
R10 |
|
|
|
|||||||||
|
2 (PB1) |
3 |
6 |
2354 |
2359 |
2248 |
2253 |
GAGATC |
(101 to 106) |
R23, R25 |
|
|
|||||||||
|
2 (PB1) |
4 |
6 |
2391 |
2396 |
2285 |
2290 |
GACGGC |
R24, R25 |
|
|
|
|||||||||
|
3 (PA) |
1 |
8 |
2140 |
2147 |
2095 |
2102 |
GAGGAGTG |
R18 |
|
|
|
|||||||||
|
3 (PA) |
2 |
6 |
2150 |
2155 |
2105 |
2110 |
TGATTA |
R18 |
|
|
|
|||||||||
|
7 (M) |
1 |
9 |
93 |
101 |
77 |
85 |
GGCCCCCTC |
R1 |
|
|
|
|||||||||
|
7 (M) |
2 |
11 |
180 |
190 |
164 |
174 |
AAGACAAGACC |
R1 |
|
|
|
|||||||||
|
7 (M) |
3 |
8 |
196 |
203 |
180 |
187 |
TGTCACCT |
R1 |
|
|
|
|||||||||
|
7(M) |
4 |
17 |
237 |
253 |
221 |
237 |
CTCACCGTGCCCAGTGA |
R2 |
|
|
|
|||||||||
|
7 (M) |
5 |
7 |
873 |
879 |
855 |
861 |
TTCAAAT |
R8 |
|
|
|
|||||||||
|
7 (M) |
6 |
8 |
945 |
952 |
927 |
934 |
ATGAGGGA |
R8 |
|
|
|
|||||||||
|
8 (NS) |
1 |
7 |
69 |
75 |
43 |
49 |
AGGTAGA |
R1 |
|
|
|
|||||||||
|
8 (NS) |
2 |
10 |
574 |
583 |
529 |
538 |
AGGATGTCAA |
R6 |
|
|
|
|||||||||
|
8 (NS) |
3 |
6 |
616 |
621 |
571 |
576 |
AATGGA |
( 368- 373) (383- 388) |
R6 |
|
|
|||||||||
|
The evolutionary conserved motifs found in four of the eight influenza segments, whose criteria are at least 6 consecutive nucleotides that are 100% conserved in all the studied strains and the location of each motif on H5N1 Refseq. Sequences and length are shown |
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|
ElHefnawi et al. Virology Journal 2011 8:44 doi:10.1186/1743-422X-8-44 |
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