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Open Access Highly Accessed Case Report

Does human bocavirus infection depend on helper viruses? A challenging case report

Monika Streiter1, Monika Malecki2, Aram Prokop1, Verena Schildgen2, Jessica Lüsebrink2, Andreas Guggemos1, Matthias Wißkirchen1, Michael Weiß1, Reinhold Cremer1, Michael Brockmann2 and Oliver Schildgen2*

Author Affiliations

1 Klinik für Kinder- und Jugendmedizin, Kinderkrankenhaus, Kliniken der Stadt Köln gGmbH, Amsterdamer Str. 59, Cologne, 50735, Germany

2 Institut für Pathologie, Krankenhaus Merheim, Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke, Ostmerheimer Str.200, Cologne, 51109, Germany

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Virology Journal 2011, 8:417  doi:10.1186/1743-422X-8-417

Published: 29 August 2011

Abstract

A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV) and human herpes virus type 6 (HHV6) is reported. The case supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or that HBoV replicates by a mechanism that is atypical for parvoviruses, or that HBoV infection can be specifically treated with cidofovir.