Table 1

Viral RNA was found in various organs depending on inoculated DENV-1 isolate (DF, DHF, or DSS), virus concentration in inoculum, and time-point p.i. In total 54.3% of the DENV-1 infected mice had detectable levels of viral RNA.

DENV isolate

DF

DHF

DSS


Titer (PFU/mL)*

1.5 × 104

1.5 × 105

1.5 × 106

1.5 × 104

1.5 × 105

1.5 × 106

1.5 × 104

1.5 × 105

1.5 × 106


Day (p.i.)**

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15

3

6

15


Heart

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-


Lungs

-

-

-

2

3

-

2

3

1

-

-

-

-

2

-

2

2

1

-

-

-

-

3

1

1

1

1


Spleen

1

-

-

-

-

-

2

-

-

1

-

-

-

-

2

2

1

-

-

1

-

-

1

1

2

-

-


Brain

-

-

-

-

-

-

1

-

-

1

1

-

-

-

-

-

3

-

-

1

2

1

3

2

-

2

-


Liver

-

-

-

-

-

-

-

-

-

-

-

-

1

1

-

2

-

-

-

-

-

-

-

-

-

-

-


Kidneys

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-


Infected mice

1

-

-

2

3

-

3

3

1

2

1

-

1

2

2

3

3

1

-

3

2

1

3

3

2

2

1


Infected mice per titer

1

5

7

3

5

7

4

7

5


Infected mice per day p.i.

6

6

1

6

6

3

3

7

6


Σ infected mice per virus isolate

13

15

16


% infected mice per virus isolate

48.2%

55.6%

59.3%


* Titer of inoculum was significant (p = 0.012).

** Time-point post-infection was significant (p = 0.014).

Tuiskunen et al. Virology Journal 2011 8:398   doi:10.1186/1743-422X-8-398

Open Data