Table 3

Phenotypes of CD4+ regulatory cells in early HCV infection

Median (range) (%)

CD4+ cells

HCV- (n = 3)

HCV+ (n = 6)

p value*


CD25+

9.50 (9.1 - 10)

20.9 (17 - 34)

0.02

TGFβ+

2.89 (1.3 - 8.4)

30.0 (25 - 37)

0.02

IL-10+

3.02 (1.6 - 5.1)

5.64 (2.0 - 16)

0.04

IFNγ+

5.04 (1.6 - 9.8)

5.14 (2.9 - 8.7)

0.81

TGFβ+ IL-10+

1.33 (0.3 - 3.4)

5.03 (1.4 - 9.3)

0.05

TGFβ+ IFNγ+

1.52 (0.7 - 5.0)

2.01 (0.9 - 6.8)

0.54

CD25-

56.0 (52 - 58)

51.3 (48 - 54)

0.07

TGFβ+

1.43 (0.7 - 4.2)

26.5 (20 - 33)

0.02

IL-10+

0.42 (NA**)

0.92 (0.5 - 6.8)

NA

IFNγ+

2.15 (0.9 - 3.2)

2.31 (0.4 - 7.3)

0.81

TGFβ+ IL-10+

0.08 (NA)

0.40 (0.2 - 2.5)

NA

TGFβ+ IFNγ+

0.07 (0.05 - 1.1)

0.70 (0.03 - 1.1)

0.2


*: Wilcoxon non-parametric t-test.

**: number of control subjects is less than 2.

Wang et al. Virology Journal 2011 8:377   doi:10.1186/1743-422X-8-377

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