Table 2

Phenotypes of CD4+CD25+ cells induced by HCV variants

Median (range) (%)

CD4+ cells

HCV- (n = 3)

HCV+ (n = 6)

p value*


Medium

CD25+

8.31 (6.0 - 11)

23.4 (19 - 28)

0.03

TGFβ+

5.28 (3.5 - 9.0)

56.0 (46 - 61)

0.01

IL-10+

3.22 (2.5 - 3.5)

7.54 (6.0 - 17)

0.04

TGFβ+ IL-10+

0.67 (2.0 - 5.5)

7.85 (5.0 - 14)

0.04

NS3358-375

CD25+

10.1 (10 - 14)

21.6 (18 - 27)

0.02

TGFβ+

5.04 (2.0 - 8.5)

55.4 (37 - 59)

0.01

IL-10+

2.95 (2.6 - 3.2)

6.51 (3.0 - 11)

0.03

TGFβ+ IL-10+

0.67 (0.5 - 2.5)

7.85 (5.0 - 12)

0.002

VP1

CD25+

10.2 (7.0 - 13)

29.9 (21 - 48)

0.01

TGFβ+

6.18 (2.0 - 14)

57.1 (42 - 61)

0.06

IL-10+

5.77 (3.5 - 7.5)

6.23 (5.0 - 13)

0.33

TGFβ+ IL-10+

7.84 (2.0 - 6.5)

8.65 (5.0 - 15)

0.21

VP2

CD25+

8.60 (5.0 - 13)

29.3 (23 - 51)

0.02

TGFβ+

7.04 (3.0 - 13)

58.8 (44 - 67)

0.04

IL-10+

6.57 (6.0 - 8.5)

7.73 (5.5 - 12)

0.36

TGFβ+ IL-10+

3.05 (2.5 - 7.0)

9.36 (5.0 - 17)

0.07


*: Wilcoxon non-parametric t-test

All subjects are positive for HLA-DRB1*15.

Wang et al. Virology Journal 2011 8:377   doi:10.1186/1743-422X-8-377

Open Data