Table 7

Quasispecies analyses of HCV in various tissues in chronic HCV-infected individuals

Patients, special groups

Cell types investigated

Regions studied

Methods

References


a. Liver, PBMC, other

End-stage liver disease

L, S, PBMC, PLN

HVR1

Seq

[41]

LT

L, S, PBMC, PLN

HVR1

HMA, Seq

[101]

LT

L, S, PBMC, PLN

HVR1

Seq

[66]

IFN α-treated and SVR occult

L, S, PBMC

5'UTR

Seq

[61]

IFN α-treated and SVR occult

L, S, PBMC, PLN

HVR1

Seq

[100]

Chronic

L, P, PBMC

HVR1

Seq

[60]

Chronic

L, S, PBMC

HVR1

Clonal frequency analysis, Seq

[212]

Chronic

L, S, PBMC

HVR1

Seq

[196]

Chronic

L, S, P, PBMC, monocytic DC

5'UTR, HVR1

Seq

[78]

Chronic

L, P, PBMC

5'UTR

INNO-LiPA

[62]

b. Liver, other

Cadavers

L, S, CNS, lymph

5'UTR, HVR1

Seq

[79]

Co-infected

L, P, CNS

5'UTR, E1

Seq

[80]

Chronic

L, S

5'UTR, E2-NS2

Seq

[86]

Chronic

L, S

E2-NS2

Seq

[87]

Chronic

L, S

E2-NS2

Seq

[88]

Chronic

L, P, CNS

5'UTR, E1

Seq

[81]

Chronic

L, S

5'UTR

SSCP, Seq

[89]

Chronic

L, PBMC, monocytic DC

5'UTR

Seq

[77]

c. PBMC, other extrahepatic

Co-infected

P, PBMC, CSF

5'UTR

Seq, INNO-LiPA

[75]

Co-infected

S, PBMC, M, B, CD4+ T, CD8+ T

5'UTR

SSCP, Seq

[70]

Co-infected

S, PBMC

HVR1

Seq

[105]

Co-infected women

P, PBMC, Genital-cervicovaginal lavage fluid (CVL)

5'UTR

SSCP, Seq

[90]

LT

S, PBMC

5'UTR

SSCP, Seq

[98]

LT

P, PBMC

HVR1

Seq

[99]

LT

S, PBMC

5'UTR

SSCP, Seq

[213]

LT

S, PBMC

NS5B

Seq

[66]

MC

P, PBMC, cryoprecipitate

5'UTR, HVR1

Seq

[65]

Chronic

P, PBMC

5'UTR, NS5B

Seq

[214]

Chronic

P, PBMC

5'UTR, HVR1

Seq

[69]

Chronic

P, PBMC

5'UTR, NS5B

SSCP, Seq, INNO-LiPA

[63]

Chronic

S, PBMC, CSF

5'UTR

SSCP, Seq

[82]

Chronic

P, PBMC

5'UTR

SSCP, Seq

[67]

Chronic

S, PBMC

HVR1,2+

Seq

[64]

d. Other extrahepatic

Cadavers

S, CNS (brain autopsies)

5'UTR

SSCP, Seq

[84]

Co-infected

S, CSF

5'UTR, HVR1

SSCP

[83]

Co-infected women

P, Genital-cervical cytobrush

5'UTR, HVR1

Seq

[91]

Co-infected men

P, Semen

HVR1

Seq

[92]

LT

S, Brain

5'UTR

SSCP, Seq

[85]

Oral lichen planus, oral cancer

Oral lichen planus, oral cancer

5'UTR, HVR1

Seq

[74]

Chronic

S, peripheral blood DC

HVR1

Seq

[72]

Chronic

P, BMC

5'UTR

SSCP, Seq, INNO-LiPA

[76]

Chronic

P, B, M, T

HVR1

Seq

[71]

Chronic

P, peripheral blood DC

HVR1

Seq

[73]

Chronic

P, M, B, CD4+ T, CD8+ T

5'UTR

Seq

[58]


Key: L = Liver; S = Serum; P = Plasma; B = B cells; T = T cells; M = Monocytes/Macrophages; DC = Dendritic cells; CSF = cerebral spinal fluid;

PLN = perihepatic lymph nodes; LT = Liver transplant; MC = mixed cryoglubulinemia; SSCP = single-strand conformational polymorphism; HMA = heteroduplex mobility;

Revie and Salahuddin Virology Journal 2011 8:346   doi:10.1186/1743-422X-8-346

Open Data