Transcriptional regulation of the genes belonging to the p53 signalling pathway (IPA canonical pathway) during influenza viral infection. Mean fold changes of the genes encoding regulators and targets of p53 that were differentially expressed by at least one virus, calculated as Log2(Mean expression levels in infected samples) - Log2(Mean expression levels in mock samples) and overlaid on the pathway in green for downregulated genes (FC < 0), and red for upregulated genes (FC > 0). Fold changes in each group of samples are depicted in the heat maps and were used to cluster hierarchically both samples and genes. Genes considered significant for each virus with the SAM procedure are indicated by a white X on the heat maps.
Terrier et al. Virology Journal 2011 8:285 doi:10.1186/1743-422X-8-285