Table 5

Jamestown Canyon virus strains are highly infectious for weanling Swiss Webster mice, are weakly neuroinvasive, and differ in neurovirulence

Virus

Neuroinvasivenessa (log10 PFU)

Neurovirulenceb (log10 PFU)

Phenotypee




LD50c

ID50d

LD50

ID50

Neuroinvasive

Neurovirulent


JCV/61/CO

4.8

0.8

1.2

0.5

Low

High

JCV/61/CO-cl

> 4

0.9

0.4

0.4

Low

High

JCV/03/CT

> 5

< 0

3.7

0.3

Low

Low

JCV/03/CT-cl

> 5

< 0

> 4

-0.5

Low

Low

JCV/04/CT-cl

> 5

0.3

1.4

< -1

Low

High


a Groups of weanling Swiss Webster mice (21-23 days old) were inoculated intraperitoneally with 100 μL of diluted virus (0 - 5 log10 PFU).

b Groups of six weanling Swiss Webster mice (21-23 days old) were inoculated intracerebrally with 10 μL of diluted virus (-1 - 4 log10 PFU).

c LD50 = Lethal dose 50%.

d ID50 = Infectious dose 50%. Infection was defined by the development of clinical disease and/or a four-fold increase in neutralizing antibody titers.

e Neuroinvasive phenotype: Low = LD50 > 3.5 log10 PFU. Neurovirulent phenotype: Low = LD50 > 3.5 log10 PFU; High = LD50 < 1.5 log10 PFU.

Bennett et al. Virology Journal 2011 8:136   doi:10.1186/1743-422X-8-136

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