The secondary infection model of EV71. Groups of 1-day-old mice were first injected with different doses (105, 106, and 107 PFU/per mouse) of an avirulent EV71 strain (HN08/08) and then challenged with a virulent EV71 strain (AH08/06) 14 days later. The surviving curves after the secondary EV71 infection was analyzed by log-rank test and significant differences are indicated by asterisks. One representation of three independent experiments is shown.
Han et al. Virology Journal 2011 8:106 doi:10.1186/1743-422X-8-106