A: Phylogenetic analysis based on the entire 3D gene. The trees were drawn on the basis of the 1368-nt sequence including the noncoding region using the Neighbor-Joining method of MEGA software (version 4.0). Solid diamond indicated the fatal cases; Solid triangle indicated the severe cases; Solid round indicated the mild cases; Triangle indicated the HEV71 sequences from other provinces in China between 1997 and 2008(available from GenBank). The scale bar indicates the number of nucleotide substitutions per site. B: similarity plot and bootscan identified the recombinant sequences in 3D region of genome of HEV71. The window size of 200-nt slides in increments of 20 nt at a time. The Kimura model with the Jukes-Cantor correction was used. The vertical axis indicates the percent nucleotide identities between strain Fuyang 2008, CV-A16, and HEV71 strain. The horizontal axis indicates the nucleotide positions of the entire genome.
Zhang et al. Virology Journal 2010 7:94 doi:10.1186/1743-422X-7-94