Table 3

Unique amino acid changes observed in four imported CHIKVs compared to 22 published strainsa

Non-structural proteins

Structural proteins



nsP1

nsP2

nsP2

nsP2

nsP3

nsP3

nsP4

C

E2

E2

6K

E1


Polypeptide position*

120

1074

1112

1167

1705

1727

2044

8

503

577

779

1125

Protein position*

120

539

577

632

372

394

181

8

178

252

31

316

FD080008

Q

L

G

N

D

M→I

P

T

R→H

K

V→I

A

SD-08-pan

Q→R

L

G→R

N→S

D→N

M

P

T

R

K

V

A

FD080178

Q

L→S

G

N

D

M

P→S

T→A

R

K→Q

V

A→V

FD080231

Q

L→S

G

N

D

M

P

T→A

R

K→Q

V

A


aTwenty-two CHIKV whole-genome sequences were selected for comparison with the imported CHIKVs, including three east/central/south African strains: S27 [GenBank:AF369024], NC004162 [GenBank:NC_004162], and ROSS [GenBank:AF490259]; 13 Indian Ocean strains: IND-00-MH4 [GenBank:EF027139], IND-06-TN1 [GenBank:EF027138], CHIK31 [GenBank:EU564335], TM25 [GenBank:EU564334], DRDE-06 [GenBank:EF210157], ITA07-RA1 [GenBank:EU244823], Wuerzburg [GenBank:EU037962], D570/06 [GenBank:EF012359], IND-06-RJ1 [GenBank:EF027137], IND-06-MH2 [GenBank:EF027136], IND-06-KA15 [GenBank:EF027135], IND-06-AP3 [GenBank:EF027134], and LR2006 OPY1 [GenBank:DQ443544]; five Asian strains: IND-60-WB1 [GenBank:EF027140], IND-73-MH5 [GenBank:EF027141], AF 15561 [GenBank:EF452493], TSI-GSD-218 [GenBank:L37661], and MY002IMR/06/BP [GenBank:EU703759]; and one West African strain: 37997 [GenBank:AY726732]. *S27 reference numbering.

Zheng et al. Virology Journal 2010 7:8   doi:10.1186/1743-422X-7-8

Open Data