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Genetic analysis of chikungunya viruses imported to mainland China in 2008

Kui Zheng, Jiandong Li, Quanfu Zhang, Mifang Liang, Chuan Li, Miao Lin, Jicheng Huang, Hua Li, Dapeng Xiang, Ninlan Wang, Ye Hong, Li Huang, Xiaobo Li, Deguan Pan, Wei Song, Jun Dai, Boxuan Guo and Dexin Li*

Virology Journal 2010, 7:8  doi:10.1186/1743-422X-7-8

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Concerns the genetic analysis of Chikungunya Virus strain China 2008 FD080178 and SD08Pan

Rishi Kumar Singh   (2010-07-14 16:29)  Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow UP, INDIA email

The article concerns the genetic analysis of Chikungunya Virus strain China 2008 FD080178, in which the authors described the variation in amino acid E1 gene, a shift of Ala to Val at amino acid 306. We are surprised to observe this information, because in Table.3 shows the unique amino acid changes, but here the E1 gene showed protein position 316 is mutated. The position mentioned in E1 A306V is wide of the mark, and the concrete protein position is E1 A316V, which only mentioned in Table.3 with position 1125 polypeptide E1 316 Ala to Val.The persuasion to author for evaluates the right mutation at this point.
We also suggested that, author missed an important point mutation at another protein position 1078 of E1 V269M in strain SD08Pan and not discussed in present article, this point mutation was presented in previous study (Schuffenecker et. al. 2006) Ross Strain (Accession No. AF490259), S27, and IND-63-WB1 (Accession No EF027140).

Competing interests

There is no competing interests (political, personal, religious,ideological, intellectual, commercial or any other) but we want to circulate the right information to all reader of your esteemed Journal.

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Concerns the genetic analysis of Chikungunya Virus strain China 2008 FD080178 and SD08Pan

Rishi Kumar Singh   (2010-05-03 14:06)  Department of Microbiology,Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow,UP,India email

The article concerns the genetic analysis of Chikungunya Virus strain China 2008 FD080178, in which the authors described the variation in amino acid E1 gene, a shift of Ala to Val at amino acid 306. We are surprised to observe this information, because in Table.3 shows the unique amino acid changes, but here the E1 gene showed protein position 316 is mutated. The position mentioned in E1 A306V is wide of the mark, and the concrete protein position is E1 A316V, which only mentioned in Table.3 with position 1125 polypeptide E1 316 Ala to Val.The persuasion to author for evaluates the right mutation at this point.
We also suggested to that, missed an important point mutation at another protein position 1078 of E1 V269M in strain SD08Pan and not discussed in present article, this point mutation was presented in previous study (Schuffenecker et. al. 2006) Ross Strain (Accession No. AF490259), S27, and IND-63-WB1 (Accession No EF027140).

Competing interests

No non-financial competing interests (political, personal, religious,ideological, intellectual, commercial or any other) but academically we want circulate the right information to all reader of your esteemed Journal.

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