Table 1

Contraindications situations for pegylated interferon and ribavirin therapy

Contraindications levels


No more contraindications

- Regular alanine aminotransferase

- Methadone maintenance

- Anemia/thrombocytopenia and neutropenia

- Restricted seizure

- Age more than 65 years

- Excess use of alcohol

Virtual contraindications

- Depression

- Psychosis

- Autoimmune disorder

- Drug abuser

- Renal failure (with dialysis)

Tough although not general contraindications

-Alcohol use

-Coronary artery disorder

- Hepatic decompensation

- Transplantation of solid organ (except liver)

General contraindications

- Pregnancy

Munir et al. Virology Journal 2010 7:296   doi:10.1186/1743-422X-7-296

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