Table 1

Mean blood chemistry values from sham- or PICV-challenged hamsters on day 7 of infectiona.

Analyte

Sham-infected

PICV-infected

P-valueb


ALB (g/dL)

5.2 ± 0.2

4.0 ± 0.3

***

ALP (U/L)c

180 ± 27

> 1914 ± 606

***

ALT (U/L)d

160 ± 74

> 1894 ± 213

***

AMY (U/L)

1659 ± 408

690 ± 227

***

TBIL (mg/dL)

0.23 ± 0.05

0.62 ± 0.61

NS

BUN (mg/dL)

25.8 ± 1.7

24.2 ± 13.4

NS

Ca++ (mg/dL)

14.2 ± 0.6

13.2 ± 0.8

*

PHOS (mg/dL)

10.6 ± 0.6

8.2 ± 1.0

***

CRE (mg/dL)e

< 0.25 ± 0.05

< 0.38 ± 0.12

*

GLU (mg/dL)

183 ± 30

80 ± 37

***

Na+ (mM)

148 ± 4

149 ± 4

NS

K+ (mM)f

> 8.5 ± 0.0

> 8.4 ± 0.1

NS

TP (g/dL)

6.3 ± 0.1

6.3 ± 0.4

NS

GLOB (g/dL)

1.1 ± 0.3

2.3 ± 0.5

***


aSham-infected, n = 6; PICV-infected, n = 10.

bStudent's two-tailed t-test. *P < 0.05, **P < 0.01, ***P < 0.001; NS, not significant.

cThree PICV-infected hamsters had saturated levels of ALP (> 2400 U/L).

dSeven PICV-infected hamsters had saturated levels of ALT (> 2400 U/L).

eOne PICV- and three sham-infected hamsters had levels below the limit of detection (0.2 mg/dL)

fSeven PICV- and six sham-infected hamsters had saturated levels of K+ (8.5 mM).

Bold font indicates analytes differing significantly between sham- and PICV-infected hamsters.

ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AMY, amylase; TBIL, total bilirubin; BUN, blood urea nitrogen; Ca++, calcium; PHOS, phosphate; CRE, creatinine; GLU, glucose; Na+, sodium; K+, potassium; TP, total protein; GLOB, globulin.

Gowen et al. Virology Journal 2010 7:240   doi:10.1186/1743-422X-7-240

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