Analysis of systemic levels of inflammatory mediators during PICV infection in hamsters. Groups of animals (n = 3-4/group) were infected with ~5 plaque-forming units of PICV, with the exception of 3 hamsters that were processed at the time of infection to establish the day 0 baseline reading. On each of days 2, and 4-7 of the infection, serum was collected from PICV-infected hamsters for multi-analyte profiling of serum antigens. Data are shown for hamster cytokines and chemokines that were sufficiently cross-reactive with the Rodent MAP® detection platform and changed significantly over the course of infection. The least detectable dose is indicated by the red hashed line and is defined in the methods. GCP, Granulocyte Chemotactic Protein; IL, Interleukin; IP, Inducible Protein; MCP, Monocyte Chemoattractant Protein; M-CSF, Macrophage-Colony Stimulating Factor; MDC, Macrophage-Derived Chemokine; MIP, Macrophage Inflammatory Protein; SCF, Stem Cell Factor; VCAM, Vascular Cell Adhesion Molecule; VEGF, Vascular Endothelial Cell Growth Factor.
Gowen et al. Virology Journal 2010 7:240 doi:10.1186/1743-422X-7-240