Longitudinal hematologic analysis of PICV infection in hamsters. Two groups of hamsters were infected with ~5 plaque-forming units of PICV or sham-infected. On each of days 0, 2, and 4-8 of the infection, blood was collected by retro-orbital venous sinus route following isoflurane anesthesia for hematologic analysis as described in the methods section. The data points represent the analysis of samples from groups of 4 hamsters with the exception of the PICV-infected group, wherein due to the death of a single animal in the on day 7, and a second hamster on day 8, the data reflect values for 3 and 2 animals, respectively, for days 7 and 8. (A) White blood cells, WBC, (B) hematocrit, HCT, (C) red blood cells, RBC, and (D) hemoglobin, Hb values are shown. m/mm3, millions per cubic milliliter of blood.
Gowen et al. Virology Journal 2010 7:240 doi:10.1186/1743-422X-7-240