Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever
1 Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA
2 Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, USA
3 Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA
Virology Journal 2010, 7:240 doi:10.1186/1743-422X-7-240Published: 16 September 2010
Additional file 1:
Figure S1: Rodent MAP® antigens. Complete 58 antigen panel of the version 2.0 Rodent MAP® system validated for interrogation of mouse serum or plasma samples. Sufficient cross reactivity of hamster factors allows for detection and measurement of relative levels for many of the antigens.
Format: TIFF Size: 110KB Download file
Additional file 2:
Figure S2: Changes in systemic levels of fibrinogen, AST, and vWF during PICV infection in hamsters. Groups of animals (n = 3-4/group) were infected with ~5 plaque-forming units of PICV, with the exception of 3 hamsters that were processed at the time of infection to establish the day 0 baseline reading. On each of days 2, and 4-7 of the infection, serum was collected from PICV-infected hamsters for multi-analyte profiling of serum antigens. Data are shown for non-cytokine/chemokine factors that were sufficiently cross-reactive with the Rodent MAP® detection platform and changed significantly over the course of infection. The least detectable dose is indicated by the red hashed line and is defined in the methods. AST, aspartate aminotransferase; vWF, Von Willebrand factor.
Format: TIFF Size: 45KB Download file