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Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever

Brian B Gowen1*, Justin G Julander1, Nyall R London2, Min-Hui Wong1, Deanna Larson1, John D Morrey1, Dean Y Li2 and Mike Bray3

Author Affiliations

1 Institute for Antiviral Research and Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, USA

2 Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, USA

3 Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA

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Virology Journal 2010, 7:240  doi:10.1186/1743-422X-7-240

Published: 16 September 2010

Additional files

Additional file 1:

Figure S1: Rodent MAP® antigens. Complete 58 antigen panel of the version 2.0 Rodent MAP® system validated for interrogation of mouse serum or plasma samples. Sufficient cross reactivity of hamster factors allows for detection and measurement of relative levels for many of the antigens.

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Additional file 2:

Figure S2: Changes in systemic levels of fibrinogen, AST, and vWF during PICV infection in hamsters. Groups of animals (n = 3-4/group) were infected with ~5 plaque-forming units of PICV, with the exception of 3 hamsters that were processed at the time of infection to establish the day 0 baseline reading. On each of days 2, and 4-7 of the infection, serum was collected from PICV-infected hamsters for multi-analyte profiling of serum antigens. Data are shown for non-cytokine/chemokine factors that were sufficiently cross-reactive with the Rodent MAP® detection platform and changed significantly over the course of infection. The least detectable dose is indicated by the red hashed line and is defined in the methods. AST, aspartate aminotransferase; vWF, Von Willebrand factor.

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