Cluster analysis of differentially- expressed genes involved in cell cycle regulation. Heat-map of gene expression levels at 3 and 7 hpi in triplicate (A, B, C). Folds of change in gene expression represented as a gradient of green and red color for low- and high-expression intensity, respectively. Each row represents one gene that met analysis cutoff of average fold change ≥1.8 in at least one of the two time points and P-value ≤ 0.05 in both. Genes fell in three cell cycle pathways with some genes functioning in more than one pathway (A) cell cycle: G1/S checkpoint regulation pathway (B) cell cycle: G2/M checkpoint regulation pathway (C) cell cycle regulation by BTG family proteins pathway.
Alkhalil et al. Virology Journal 2010 7:173 doi:10.1186/1743-422X-7-173