Up- and down-regulated transcripts follow different distribution patterns during infection progression. Each bar represents average fold-change ratios (FCRs) of gene expression at 7 hpi/3 hpi for either 100 consecutive downregulated genes (A), or 10 upregulated genes (B), after sorting all genes according to their FCR values from smallest to largest. Genes with average FCR values < 1 are in grey and those with values > 1 are in black. Results show most downregulated genes maintained an increasing suppression trend in the course of infection as more than 92% of the genes gave fold-change ratio > 1 (A). The 295 upregulated genes exhibited more balanced distribution between 7 and 3 hpi with about 51% of the genes having higher fold change at early time point.
Alkhalil et al. Virology Journal 2010 7:173 doi:10.1186/1743-422X-7-173