Figure 8.

MPV CDV-R substitutions mapped onto the 3-D structure of S. cerevisiae RNA pol II (GenBank # CAA65619.1). The MPV CDV-R L653R residue mapped to the yeast RNA pol II funnel domain is designated in yellow (A-C). The MPV CDV-R K355N residue mapped to the docking domain of yeast RNA pol II is designated in orange. Yeast residues Leu737 (blue) and Phe755 (magenta) are associated with α-amanitin resistance [46]. Illustrations were prepared using PyMol.