Table 1

Overview HPV internalization studies

HPV type

Methods

Pathway

Reference


HPV16

siRNA-mediated down regulation of clathrin heavy chain/caveolin-1/dynamin/tetraspanins

dominant negative mutants of EPS15/caveolin-1/dynamin

biochemical inhibitors

caveolae-deficient cells

clathrin- and caveolae-independent

dynamin-independent

lipid raft independent

involvement of tetraspanins

[58]

HPV16

HPV31

biochemical inhibitors

clathrin-dependent

[66]

HPV16

HPV31

dominant negative mutant of EPS15/caveolin-1/dynamin-2

biochemical inhibitors

co-localization studies of HPV16 and HPV31

association study of HPV31 with detergent resistant microdomains

HPV16 clathrin-dependent

HPV31 caveolae-dependent

[65]

HPV16

co-localization with BPV-L1 VLPs

clathrin-dependent

[63]

HPV16

HPV31

HPV58

biochemical inhibitors

microscopic analysis

HPV16/58 clathrin-dependent

HPV31 caveolae-dependent

[64]

HPV33

biochemical inhibitors

non-caveolae dependent HPV33 uptake

[59]


Horvath et al. Virology Journal 2010 7:11   doi:10.1186/1743-422X-7-11

Open Data