Table 4

Selective pressure on different sites between human and avian influenza

Human

Avian


Gene

Domaina

Position

dN/dSb

P-value

dN/dS

P-value


M1

115

0.07

    0.0031

0.06

    < 0.001

121

0.11

    0.039

0.07

    < 0.001

137

0.69

0.61

0.03

    < 0.001


M2

ex

11

infc

0.017

inf

< 0.001

ex

16

6.18

0.021

5.06

0.044

ex

20

Inf

0.094

inf

< 0.001

cy

54

1.36

0.50

0.50

    0.12

cy

57

3.62

0.050

inf

0.12

cy

78

0.74

    0.68

0.26

    0.086

cy

86

3.47

0.16

0.64

    0.64

cy

93

1.27

0.71

inf

0.067


aEx indicates extracellular domain; Tr, transmembrane domain; and Cy, cytoplasmic domain.

bdN/dS was calculated by eFEL.

c"inf" means infinity as denominator is 0.

Significance of the FEL test for positive selection levels is given as P-values, and underlined values indicate P-values for negative selection.

Bold values are those deemed to indicate significantly positive or negative selection (P < 0.05).

Furuse et al. Virology Journal 2009 6:67   doi:10.1186/1743-422X-6-67

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