Lactoferrin but not lysozyme inhibited efficiently HSV-1 infection of Vero cells. Replication of wt HSV-1 and mutant viruses gC-39 and Rid1 in Vero cells with human non-iron-saturated Lf (apoLf), iron-saturated Lf (satLf) or lysozyme (hLz) present throughout the entire replication cycle. Lactoferrin and lysozyme were added to cell cultures 24 h prior to infection. The relative amount of viral plaques, in comparison to untreated cultures, is shown. Error bars represent standard deviations of three separate experiments. Statistical significance in the level of inhibition: * = p < 0.05, ** = p < 0.005, mutant viruses compared to wt KOS. Only results with the highest concentration of hLz used are shown.
Välimaa et al. Virology Journal 2009 6:53 doi:10.1186/1743-422X-6-53