Table 1

drug resistant mutation sites of primary variants and variants after culture 4 weeks

first variants

fourth variants



Virus variants

tropism

NRTIs

NNRTIs

NRTIs

NNRTIs


V1

R5X4

-

K103N

-

-

V2

R5

-

K101*EKQ, Y181C, G190A

-

G190A

V3

R5X4

T215Y

K103N, Y181C

T215Y

K103N, Y181C

V4

R5X4

D67N, K70R, T215F, K219Q

K103N, Y181C

D67N, K70R, T215F, K219Q

K103N, Y181C

V5

R5X4

    L74V

Y181C

    V75T

V108I, Y181C

V6

R5X4

-

K103N, Y181C

-

K103N, Y181C

V7

R5X4

M41L, L74V, T215F

K101E, Y181C, G190S

M41L, L74V, T215F

K101E, Y181C, G190S

V8

R5

K65R

K103N, Y181C

K65R

K103N, Y181C

V9

R5

T69APST

V108FILV

-

-

V10

R5

M41LM, T215Y

K103N, G190A

T215Y

K103N, G190A

V11

R5X4

A62V, K70KN, V75T

Y188L

K70N, V75T

Y188L

V12

R5X4

-

    G190EV

-

    G190A

V13

R5

-

-

-

Y181C


-: none; bold: lost after culture; bold and italic: emergent after culture; bold and

    underline
: changed after culture.

Sun et al. Virology Journal 2009 6:201   doi:10.1186/1743-422X-6-201

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