Table 1 |
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|
drug resistant mutation sites of primary variants and variants after culture 4 weeks |
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|
first variants |
fourth variants |
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|
|
|
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|
Virus variants |
tropism |
NRTIs |
NNRTIs |
NRTIs |
NNRTIs |
|
|
|||||
|
V1 |
R5X4 |
- |
K103N |
- |
- |
|
V2 |
R5 |
- |
K101*EKQ, Y181C, G190A |
- |
G190A |
|
V3 |
R5X4 |
T215Y |
K103N, Y181C |
T215Y |
K103N, Y181C |
|
V4 |
R5X4 |
D67N, K70R, T215F, K219Q |
K103N, Y181C |
D67N, K70R, T215F, K219Q |
K103N, Y181C |
|
V5 |
R5X4 |
L74V |
Y181C |
V75T |
V108I, Y181C |
|
V6 |
R5X4 |
- |
K103N, Y181C |
- |
K103N, Y181C |
|
V7 |
R5X4 |
M41L, L74V, T215F |
K101E, Y181C, G190S |
M41L, L74V, T215F |
K101E, Y181C, G190S |
|
V8 |
R5 |
K65R |
K103N, Y181C |
K65R |
K103N, Y181C |
|
V9 |
R5 |
T69APST |
V108FILV |
- |
- |
|
V10 |
R5 |
M41LM, T215Y |
K103N, G190A |
T215Y |
K103N, G190A |
|
V11 |
R5X4 |
A62V, K70KN, V75T |
Y188L |
K70N, V75T |
Y188L |
|
V12 |
R5X4 |
- |
G190EV |
- |
G190A |
|
V13 |
R5 |
- |
- |
- |
Y181C |
|
|
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|
-: none; bold: lost after culture; bold and italic: emergent after culture; bold and underline: changed after culture. |
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|
Sun et al. Virology Journal 2009 6:201 doi:10.1186/1743-422X-6-201 |
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