A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives

doi:10.1186/1743-422X-6-144

Virology Journal

Volume 6

Viewing options:

Abstract
Full text
PDF (569KB)
Additional files

Associated material:

Related literature:

Articles citing this article
on BioMed Central
on Google Scholar
on ISI Web of Science
on PubMed Central
Other articles by authors
on Google Scholar

Sabath N
Price N
Graur D

on PubMed

Sabath N
Price N
Graur D
Related articles/pages
on Google

on Google Scholar

on PubMed

Tools:

Post to:

Research

A potentially novel overlapping gene in the genomes of Israeli acute paralysis virus and its relatives

Niv Sabath , Nicholas Price and Dan Graur

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA

author email corresponding author email

Virology Journal 2009, 6:144doi:10.1186/1743-422X-6-144


Published:	17 September 2009

Abstract

The Israeli acute paralysis virus (IAPV) is a honeybee-infecting virus that was found to be associated with colony collapse disorder. The IAPV genome contains two genes encoding a structural and a nonstructural polyprotein. We applied a recently developed method for the estimation of selection in overlapping genes to detect purifying selection and, hence, functionality. We provide evolutionary evidence for the existence of a functional overlapping gene, which is translated in the +1 reading frame of the structural polyprotein gene. Conserved orthologs of this putative gene, which we provisionally call pog (predicted overlapping gene), were also found in the genomes of a monophyletic clade of dicistroviruses that includes IAPV, acute bee paralysis virus, Kashmir bee virus, and Solenopsis invicta (red imported fire ant) virus 1.