Ability of synthetic 3-hydroxy lauric acid to inhibit HIV infectivity. Increasing concentrations of 3-hydroxy lauric acid were incubated with HIV and added to HeLa37 cells. At 40 h following infection, cells were fixed and evaluated for HIV antigen staining. The cellular cytotoxicity of 3-hydroxy lauric acid was evaluated in parallel, in the absence of HIV. The findings are shown as percent control values (the cytotoxicity or number of HIV antigen-positive cells in the presence of the various concentrations of 3-hydroxy lauric acid divided by the cytotoxicity or number of HIV antigen-positive cells in the absence of the compound). Studies were performed three times in triplicate and shown are means and standard error of the means. *p = 0.05. **p = 0.005; ***p = 0.0001.
Maury et al. Virology Journal 2009 6:101 doi:10.1186/1743-422X-6-101