Complete genome of a European hepatitis C virus subtype 1g isolate: phylogenetic and genetic analyses

doi:10.1186/1743-422X-5-72

Virology Journal

Volume 5

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Bracho MA
Saludes V
Martró E
Bargalló A
González-Candelas F
Ausina V

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Saludes V
Martró E
Bargalló A
González-Candelas F
Ausina V
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Research

Complete genome of a European hepatitis C virus subtype 1g isolate: phylogenetic and genetic analyses

Maria A Bracho¹^,4 , Verónica Saludes²^,4 , Elisa Martró²^,4 , Ana Bargalló³ , Fernando González-Candelas¹^,4 and Vicent Ausina²^,5

¹Institut "Cavanilles" de Biodiversitat i Biologia Evolutiva, Universitat de València, Paterna (València), Spain

²Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain

³Servei d'Aparell Digestiu, Hospital Universitari Germans Trias i Pujol, Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain

⁴CIBER en Epidemiología y Salud Pública (CIBERESP), Spain

⁵CIBER en Enfermedades Respiratorias (CIBERES), Spain

author email corresponding author email

Virology Journal 2008, 5:72doi:10.1186/1743-422X-5-72


Published:	5 June 2008

Abstract

Background

Hepatitis C virus isolates have been classified into six main genotypes and a variable number of subtypes within each genotype, mainly based on phylogenetic analysis. Analyses of the genetic relationship among genotypes and subtypes are more reliable when complete genome sequences (or at least the full coding region) are used; however, so far 31 of 80 confirmed or proposed subtypes have at least one complete genome available. Of these, 20 correspond to confirmed subtypes of epidemic interest.

Results

We present and analyse the first complete genome sequence of a HCV subtype 1g isolate. Phylogenetic and genetic distance analyses reveal that HCV-1g is the most divergent subtype among the HCV-1 confirmed subtypes. Potential genomic recombination events between genotypes or subtype 1 genomes were ruled out. We demonstrate phylogenetic congruence of previously deposited partial sequences of HCV-1g with respect to our sequence.

Conclusion

In light of this, we propose changing the current status of its subtype-specific designation from provisional to confirmed.