|
Chemokines encoded by human viruses and their human and murine chemokine receptor targets. |
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| Virus |
Gene |
Protein |
human chemokine receptor targets |
Ref |
also targeting the corresponding murine chemokine receptor |
Ref |
|
|
||||||
| CMV |
UL146 |
vCXCL1 |
Selective CXCR2 agonist |
11 |
No |
20 |
| UL147 |
vCXCL2 |
? |
||||
| HHV6a |
U83B |
vCCL4 |
Selective CCR2 agonist |
9 |
? |
|
| HHV8 |
K6 |
vCCL1 (vMIP-I) |
Selective CCR8 agonist |
3,5,10 |
Yes |
18 |
| K4 |
vCCL2 (vMIP-II) |
Broadspectrum chemokine receptor |
||||
| antagonist |
||||||
| CCR1 |
6,7 |
Yes |
19 |
|||
| CCR2 |
6,7 |
Yes |
19 |
|||
| CCR5 |
6,7 |
Yes |
19 |
|||
| XCR1 |
7 |
No |
This paper |
|||
| CX3CR1 |
7 |
? |
||||
| CXCR4 |
6,7 |
? |
||||
| CCR3 agonist |
17 |
? |
||||
| K4.1 |
vCCL3 (vMIP-III) |
Selective XCR1 agonist |
10 |
No |
This paper |
|
| MCV |
MC148 |
MCC |
Selective CCR8 antagonist |
7 |
No |
18 |
|
aThe protein product from the U83 gene of HHV6A has not been included as its signal sequence include a premature stop codon. | ||||||
Lüttichau Virology Journal 2008 5:50 doi:10.1186/1743-422X-5-50 |
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