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The proportion of subjects who seroconverted or cleared serum HBV DNA by age of recruitment and interval after recruitment |
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| a) HBsAg seroconversion |
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| Age (yrs) at recruitment |
Interval after recruitment |
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| First 5 years |
5–9 years |
10–19 years |
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| *1–4 |
18/60 (30%) |
1/33 (3.3%) |
1/29 (3%) |
| *5–9 |
13/62 (21%) |
0/27 |
0/22 |
| 10–14 |
7/23 (30%) |
0/4 |
0/5 |
| 15–19 |
4/15 (27%) |
0/0 |
0/0 |
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| b) |
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| HBeAg seroconversion |
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| Age (yrs) at recruitment |
First 5 years |
5–9 years |
10–19 years |
| *1–4 |
12/36 (33%) |
6/16 (37%) |
7/10 (70%) |
| *5–9 |
10/29 (34%) |
4/12 (33%) |
5/7 (71%) |
| 10–14 |
4/11 (36%) |
1/2 (50%) |
1/1 (100%) |
| 15–19 |
1/4 (25%) |
0/0 |
0/0 |
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| c) |
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| Serum HBV DNA clearance |
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| Age (yrs) at recruitment |
First 5 years |
5–9 years |
10–19 years |
| *1–4 |
8/23 (34.7%) |
4/12 (33.3%) |
2/16 (12.5%) |
| *5–9 |
5/29 (17.2% |
3/11 (27.2%) |
1/12 (8.3%) |
| 10–14 |
1/9 (11.1%) |
0/2 (0%) |
0/4 (0%) |
| 15–19 |
1/3 (33.3%) |
0/0 |
0/0 |
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*The p-values for the test of trend over time for the first five years after recruitment is < 0.01, < 0.01 and < 0.05 for HBsAg, HBeAg and HBV DNA respectively. | |||
Mendy et al. Virology Journal 2008 5:49 doi:10.1186/1743-422X-5-49 |
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