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a. Changes in HBsAg, HBeAg and HBV DNA prevalence with time in carriers detected between 1–4 years of age |
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| Years after recruitment |
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| Serological markers |
0 |
5 |
9 |
19 |
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| HBsAg sero positivity (%) |
68/68* (100) |
42/60 (70.0%) |
33/47 (70.2%) |
37/53 (70.0%) |
| HBeAg seropositivity (%) |
57/68* (83.8%) |
25/42 (59.5%) |
12/33 (36.3%) |
5/53 (13.6%) |
| HBV DNA positive |
62/62* (100%) |
15/24 (62.5%) |
20/39 (60.6%) |
30/34 (88.2%) |
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| b) |
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| HBeAg positive carriers |
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| 0 |
5 |
9 |
19 |
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| Those with detectable HBV DNA |
46/46 (100%) |
9/9 (100%) |
6/7 (85.7%) |
5/5 (100%) |
| Those with viral load > 105 copies/mL) |
46/46 (100%) |
9/9 (100%) |
6/7 (85.7%) |
5/5 (100%) |
| Geometric Mean HBV DNA (copies/mL) |
4.5 × 108 |
1.1 × 108 |
4.4 × 108 |
8.4 × 108 |
| Median HBV DNA (copies/mL) |
1.0×109 |
3.5×108 |
1.5×109 |
5.0×108 |
| IQR (copies/mL) |
5.0 × 108–2.0 × 09 |
5.0 × 107–6.5 × 108 |
5.5 × 108–6.5 × 109 |
4.0 × 108–2.5 × 109 |
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| c) |
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| HBeAg negative carriers |
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| 0 |
5 |
9 |
19 |
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| Those with detectable HBV DNA |
11/11 (100%) |
2/7 (28.6%) |
10/14 (71.4%) |
28/31 (90.3%) |
| Those with high viral load (> 105 DNA copies/mL) |
2/11 (18.2%) |
1/7 (14.2%) |
1/14 (7.1%) |
3/31 (9.6%) |
| Geometric mean HBV DNA (copies/mL) |
7.7 × 107 |
2.1 × 108 |
1.8 × 103 |
4.2 × 103 |
| Median HBV DNA IQR (copies/mL) |
2.0 × 104 |
2.0 × 105 |
2.0 × 103 |
1.0 × 103 |
| IQR (copies/mL) |
5.0 × 103–8.0 × 104 |
**3.6 × 104–5.2 × 108 |
1.0 × 103–1.0 × 104 |
4.0x × 102-7.5 × 103 |
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*The p-values for difference in prevalence between the first two time points are < 0.006 for HBsAg, < 0.001 for HBeAg and HBV DNA respectively.**One carrier who is HBeAg negative had high serum DNA level (5.2 × 108) at the second follow up point. | ||||
Mendy et al. Virology Journal 2008 5:49 doi:10.1186/1743-422X-5-49 |
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