Figure 1.

(A) T-Coffee alignment of viral and murine profilin sequences visualized with the Base-By-Base interface. Minor manual adjustments were made to the alignment based on structural analysis. Shading of individual residues indicates the degree of residue conservation between sequences (darkest = identical aa in all sequences; no shading = zero conservation). A consensus sequence is shown below the alignment. (B) Phylogenetic tree using maximum likelihood analysis for the mammalian profilin sequences available in GenBank, and ECTV-PH. The percentage bootstrap support (100 samples) is indicated along the branches.