Genomic structure of poliovirus type 1 (Mahoney) [PV1(M)] and proteolytic processing of its polyprotein. (A) The PV genome consists of a single-stranded, positive-sense polarity RNA molecule, which encodes a single polyprotein. The 5' non-translated region (NTR) harbors two functional domains, the cloverleaf and the internal ribosome entry site (IRES), and is covalently linked to the viral protein VPg. The 3'NTR is poly-adenylated. (B) The polyprotein contains (N terminus to C terminus) structural (P1) and non-structural (P2 and P3) proteins that are released from the polypeptide chain by proteolytic processing mediated by virally-encoded proteinases 2Apro and 3Cpro/3CDpro to ultimately generate eleven mature viral proteins . Three intermediate products of processing (2BC, 3CD, and 3AB) exhibit functions distinct from those of their respective final cleavage products.
De Jesus Virology Journal 2007 4:70 doi:10.1186/1743-422X-4-70