The alignment of amino acids 241–419 and 481–540 of the potential capsid protein of Carlow virus, with the corresponding proteins of 12 post and 11 pre 2002 viruses. The red circle indicates amino acids conserved prior to 2002 which have been substituted for an amino which are conserved in the majority of viruses after 2002 (exception Lanzhou/35666/2002/china and Yuri 32073/Japan). These changes are to un-conserved amino acids, acidic to basic for example. The thick black line shows the RGD motif and 3 additional motifs responsible for strain specific binding of the human blood group antigens .
Kearney et al. Virology Journal 2007 4:61 doi:10.1186/1743-422X-4-61