HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system

doi:10.1186/1743-422X-4-57

Virology Journal

Volume 4

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DeHart JL
Zimmerman ES
Ardon O
Monteiro-Filho CM
Argañaraz ER
Planelles V

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Zimmerman ES
Ardon O
Monteiro-Filho CM
Argañaraz ER
Planelles V
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HIV-1 Vpr activates the G₂checkpoint through manipulation of the ubiquitin proteasome system

Jason L DeHart¹^* , Erik S Zimmerman¹^* , Orly Ardon¹ , Carlos MR Monteiro-Filho² , Enrique R Argañaraz² and Vicente Planelles¹

¹Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East #2100 – Room 2520, Salt Lake City, UT 84112, USA

²Laboratório de Farmacologia Molecular (CP 04536), Faculdade de Saude, Universidade de Brasília, 70919-970 Brasília, DF, Brazil

author email corresponding author email* Contributed equally

Virology Journal 2007, 4:57doi:10.1186/1743-422X-4-57


Published:	8 June 2007

Additional files

Additional file 1:

Cell cycle profiles for experiments on the role of the ubiquitin proteasome system in Vpr-induced G₂arrest, corresponding to data shown in Figure 1.

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Additional file 2:

Cell cycle profiles for experiments on the role of DCAF1 in Vpr-, etoposide- and aphidicolin-induced G₂arrest, corresponding to data shown in Figure 2B.

Format: JPEG Size: 152KB Download file

Additional file 3:

Cell cycle profiles for experiments showing the dominan-negative activity of Vpr(R80A), corresponding to data shown in Figure 4.

Format: JPEG Size: 333KB Download file