Table 1

Nonsynonymous adventitious mutations identified in rDEN1/4 chimeric viruses after passage in Vero cells
Virus
 Gene/region
 Nucleotide
 Amino acid




Number1
 Change
 Number2
 Change
rDEN1/4(CME)
 NS4B
 7134
 A → G
 102
 Thr → Ala

NS4B
 7156
 U → C
 109
 Val → Ala
rDEN1/4Δ30(CME)
 NS2B
 4269
 A → G
 45
 Ser → Gly

NS4B
 7132
 C → U
 101
 Pro → Leu
rDEN1/4(ME)
 NS4B
 7162
 U → C
 112
 Leu → Ser
rDEN1/4Δ30(ME)
 prM
 603
 C → G
 55
 Arg → Gly

NS4B
 7182
 G → C
 119
 Gly → Arg

3' UTR
 10471
 G insertion
 --
 --

1 Nucleotide numbering is from 5' genome end.

2 Amino acid numbering is according to position in respective protein product.

Blaney et al. Virology Journal 2007 4:23   doi:10.1186/1743-422X-4-23