|
Correlation between M2e-specific serum Ab titer and reduction of virus titer in various sites of the respiratory tract after parenteral and i.n. immunization. |
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| Specificity/Isotype of anti-M2e Abs |
Spearman correlation coefficient r (p) |
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|
|
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| parenteral vaccination |
i.n. vaccination |
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|
|
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| Nose |
Trachea |
Lung |
Nose |
Trachea |
Lung |
|
|
|
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| M2e(pep) |
0.07 |
-0.03 |
0.18 |
0.2 |
0.24 |
0.02 |
| M2e(pep-nat) |
0.96(***) |
0.82 (**) |
0.8 (**) |
-0.38 |
-0.27 |
-0.31 |
| M2e(pep-nat) G2a |
0.56 |
0.51 |
0.75 (*) |
-0.43 |
-0.30 |
-0.35 |
|
Mean (4–5 mice/group) M2e-specific serum Ab titers 7–10 days before challenge with X31 virus (5 μl, 103 TCID50) were analyzed for correlation with mean reduction (compared to control group) of virus titers in nose, trachea and lung. Included in the analysis are 9 groups of mice immunized with M2e-MAP by a parenteral route (s.c., i.m., i.p.) and 14 groups immunized by the i.n. route. Statistical significance of correlation (Spearman r, non parametric) is indicated by asterisk: (*): p < 0.05, (**): p = 0.01, (***): p = 0.002. | ||||||
Mozdzanowska et al. Virology Journal 2007 4:118 doi:10.1186/1743-422X-4-118 |
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